Patients with kidney and vascular diseases need innovative solutions that deliver clinically meaningful benefits.
Hemodialysis Vascular Access
To undergo hemodialysis, a patient with chronic kidney disease (CKD) must have a vascular access that provides sufficiently high blood flow to complete a dialysis session in approximately four hours. Vascular access is a patient’s lifeline — without this lifeline, a patient cannot receive this life-saving treatment. The preferred form of vascular accessis is a radiocephalic arteriovenous fistula, which is created when a surgeon connects a vein to an artery, near the wrist.
Unfortunately, up to 70% of radiocephalic fistulas fail within the first year after surgical creation due to a partial or complete blockage. This first failure is known as primary patency loss. We are not aware of any approved preventative treatments to reduce the failure rate of radiocephalic fistulas. Since a functioning vascular access is required for hemodialysis, patency loss must be addressed urgently through corrective procedures such as surgical revision or angioplasty. These procedures are invasive, painful, associated with a number of complications, carry substantial cost and can be traumatic for patients. While corrective procedures may help in the short-term, fistulas that require these interventions often do poorly in the long-term. Procedures to restore fistula patency often cannot re-establish sufficient blood flow, and the fistula must be abandoned, known as secondary patency loss, necessitating a new vascular access to enable ongoing hemodialysis. Until the new access becomes usable for hemodialysis, a process that can take months, the patient must dialyze with a catheter, which is considered the least desirable form of vascular access and is associated with increased morbidity and mortality due to infections.
Physician and Patient Perspectives
By tackling the difficult challenges facing patients with kidney disease, we aim to address the urgent demand for new treatments to improve patient outcomes. Hear directly from patients and physicians here.
Peripheral Artery Disease
Patients with PAD experience a blockage in the arteries providing blood to the legs. Patients with PAD often experience reduced quality of life, with daily activities significantly curtailed by leg pain that only abates with rest. Patients may also experience leg pain at rest, gangrene or tissue death, and may require amputation. Many patients with PAD do not receive meaningful symptom relief from lifestyle modification, exercise, or medical therapy. For these patients, the next option is typically an invasive revascularization procedure such as open surgical bypass or angioplasty. These procedures often lack durability, resulting in recurring symptoms for patients.