Patients with kidney and vascular diseases need innovative solutions that deliver clinically meaningful benefits.
Hemodialysis Vascular Access
Patients with chronic kidney disease (CKD) requiring hemodialysis must have a functioning vascular access that provides sufficiently high blood flow to complete a dialysis session in approximately four hours. Vascular access is a hemodialysis patient’s lifeline, without which a patient cannot receive this life-saving treatment.
The preferred form of vascular access is a radiocephalic arteriovenous fistula, which is created when a surgeon connects a vein to an artery in the forearm. Unfortunately, radiocephalic fistulas suffer from a high rate of failure during the first year, typically due to insufficient blood flow, which precludes hemodialysis.
Up to 40% will be abandoned (secondary patency loss)
More than 50% will fail to be used for hemodialysis because the fistula either has inadequate blood flow or cannot be successfully cannulated
Up to 70% will experience either a thrombosis or undergo a corrective procedure to restore or maintain blood flow (primary patency loss)
In hemodialysis patients, the consequences of fistula abandonment or non-use can be severe, including a reduction in dialysis adequacy and one or more additional surgical procedures to create a new vascular access. Patients will also be subjected to the potentially severe consequences of catheter exposure including:
Reduced quality of life
2x mortality risk in the 1st year
2x rate of hospitalization in the first 6 months
Physician and Patient Perspectives
By tackling the difficult challenges facing patients with kidney disease, we aim to address the urgent demand for new treatments to improve patient outcomes. Hear directly from patients and physicians here.
Peripheral Artery Disease
Patients with PAD experience a blockage in the arteries providing blood to the legs, often resulting in reduced quality of life, with daily activities significantly curtailed by leg pain that only abates with rest. Patients may also experience leg pain at rest, gangrene or tissue death, and may require amputation. Many patients with PAD do not receive meaningful symptom relief from lifestyle modification, exercise, or medical therapy. For these patients, the next option is typically an invasive revascularization procedure such as open surgical bypass or angioplasty. These procedures often lack durability, resulting in the potential for repeat interventions, symptom recurrence and disease progression.